Do not trifle with Isabella, she-wolf of France. Hugh Despenser the younger and Edmund Fitzalan brought before Isabella for trial in 1326. After sentencing, Isabella had them executed. She also conspired to remove her husband, Edward II, ...from the throne and had him murdered, possibly via anal evisceration with a red-hot iron poker. (Edward was possibly bisexual, having several male favorites).
Abaelardus and Héloïse in a 14th century Roman de la Rose. Abelard was Heloise's tutor. The two had an illicit affair, and Heloise bore a son. Heloise's uncle, her guardian, had Abelard castrated. Abelard became a monk, Heloise a prioress, but the two continued to write love letters.